The MAM Supreme Night Pacifier for 16+ months combines MAM's most beloved features. First, the nipple puts less pressure on babies' jaws and teeth and is 60% and 4x more flexible** than a regular pacifier. It is clinically proven* to reduce the risk of open bite and increased overbite later in life. Second, the wide openings on the pacifier shield create maximum air flow to protect baby's sensitive skin and prevent irritation. Third, these glow in the dark pacifiers helps keep baby's pacifier in sight. MAM’s medically engineered nipples feature life-like, SkinSoft textured silicone that feels more natural. Use the included self-sterilizing storage case to disinfect the pacifiers for up to 48 hours. Fill case with water, place pacifier in the case with the nipple facing down and follow package instructions for microwave setting. Cool completely before use. *Y. Wagner, R. Heinrich-Weltzien, “Effect of a thin-neck pacifier on primary dentition: a randomized controlled trial”, Orthodontics & Craniofacial Research, Vol. 19, Issue 3, pp. 127-136, August 2016.**Wild Hi-Precision Institute: the MAM nipple neck is approx. 60% thinner; University Clinic of Dentistry Vienna: approx. 4x more flexible than other pacifiers. (32% - 83% thinner / 1.1 - 19.5x more flexible).